I have always used topical tx. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. He is my first dog, he is 5yrs old now, and this is all new. around 12 years She grabs and won't let go. And yeah he ate today 4 chicken breast and appeared to want it even better. He was diagnosed with "Sundowners" . My 11 year old mini Aussie has been taking Simparica 1.5 years. Now her dog is very sick and she has to take the dog to the vet every day in the past week. I am hopeful he will make it through the next few weeks. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Best of luck. It was the first time she had taken Simparica. What number do we call for FDA? Gave Simparica to my dog yesterday. Currently we are monitoring him closely-hes never been sick. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. My vet prescribed my 16 week old puppy this drug because of a skin irritation. Never ever again with this med for him. My dog is still having tremors 5 months after taking Simparica. The same thing possibly is happening to my 9 month old Boxador. You don't think I'm going to continue with this poison. Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. I feel like this drug was pushed by my vet tech and veterinarian. . Getting him to go out was nearly impossible. She's a Brittany (Spaniel). His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! four times. This is so awful. My sweet, funny, smart as can be baby girl died on 9/26/20. The vet has not been able to diagnose a cause. I have ordered what I normally use and will throw this in the trash! We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. She also started drinking excessively, and peeing in the house. But today, after he ate dinner and drank water, it all came back up. Other signs may include: Lethargy Loss of appetite Most of us dog parents use some form of heartworm prevention for our dogs. Each medication combats different pests. I do believe it caused her blindness. Thank you all so much for this thread and giving me hope. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Same thing has happened to my 5 month old puppy after taking simparica. I've sent this thread and loads of other information to my vet and zoetis. This past October he just wasn't the same. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Now we are waiting for the verdict: whether its an infection in his bladder or stones. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. Im throwing away the remaining 5 pills and going back to a topical medicine. Ticks are horrible here in Maine. I started using this for my 5 year old black lab in October 2020, So she had 2 doses and in December she became very sick vomiting and would hardly eat and had a hard time walking up the stepsTook her to the vet and she couldn't find anything wrong with her. I have been giving my lab puppy (6 months old now) Simparica Trio since October. They both got similar issues and this was the only thing they both did. I PRAY that our baby is okay with this second dose. Did you go to the vets or not? It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. Revolution has been around decades with less incidents of animal reactions. Puppy is having seizures and has aspirated pneumonia. Use with caution in dogs with a history of seizures or neurologic disorders. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. The older of the 2 Poodles seemed to do fine but my younger Poodle who was about 3 years old was definitely affected and we had a difficult time even getting him to eat for at least 2 weeks. If she recovers, cause is the Simparica. I'm besides myself. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. Just a little nervous !! It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. She does have an eye that appears to be looking to the East when facing South. I am SOOO angry! The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. Hopefully yours will be lucky and return to normal. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. The following day he died. Eat grass and vomit. She spent 4 nights at the University of Auburn emergency room and vet clinic. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Can you tell me if your dog is back to normal now?!?! The .gov means its official.Federal government websites often end in .gov or .mil. He collapsed & went limp in my arms . My one year old has severe diarrhea and is very agitated and anxious. Hes been on it for six months. As I read all the comments I am so alarmed. Advised her to put a big note on our account that she is never to have this again. Get the dog moms and dads in your life something unique this year. I threw him his ball and he actually was interested in it. When did you stop giving the Simparico Trio? This time I am seeing a little blood or tissue in her stool. Good luck. Don't risk the well-being of your beloved dog just because something is more convenient. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. Hoping for good news with your pup!! so what about her puppies I am so worried. My Labradoodle had extreme diarrhea last night. I am more than upset, I am effing pissed, my poor little boy. Head down, tail down, will stand in a corner and stare at the wall. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. Please advise! I give my dogs Simparica at the beginning of each month. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. The whole packet is going in the bin !! Before he took his first doe of Simparica he was fast running, and flying through the house and yard. We received the first dose of this medication from our Vet! It's been a little over two months since her last dose and feel certain that is what almost killed her. Nexgard can cause lethargy and a loss of appetite in dogs. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. My beautiful boxer lost his appetite after just one dose of Simparica. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. I'll be calling them tomorrow. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. There is NO other explanation for this rapid decline and the only change has been THIS drug. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. Simparica only offers chewables. Tuesday morning she woke up with horrible diarrhea. She walks around as if she is on ice with no control of her back legs. He's a 1 1/2 y.o. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. My 8 month old labradoodle has had 2 doses of Simparico Trio. So I started searching and came across this blog and my heart just sank. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. I keep praying she will recover and I feel so guilty for giving it to her. He eats and drinks fine but looks like we havent fed him in days. She became extremely lethargic and feverish so we rushed her to Hospital. He started having skin issues that the vet said were allergic reactions probably due to environmental things. . I gave the 1st one to my dog, 1st of this month. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. My 6 year old Chihuahua has been on simparica trio for 4 days . That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. Seizure meds arent working. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. This happened the same to my dog.. how si going now with your pet? And now I'm upset with myself for giving this to my dog without doing research. These are classic neurological symptoms, exactly what our Pickles had before she passed. No problem eating. My vet recommended the tablet to save on monthly costs for flea and tick treatment. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. I called the vet and am putting him back on Heartgard and Nexgard. Plan to take him to see the vet tomorrow. Any tips on how to flush it from her system ? Needless, to say I will not be giving them the simparica trio again. Barely eats, but is drinking lots of water. Meaning he is suppose to get it today. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. Hello to everyone and I am so sorry we had to meet under these circumstances. The personality change is what has me most concerned too. She would constantly twirl in left circles. Previously B was on Heartgard and Advantix worked well I guess we switch back. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. I gave this to my 4 month old puppy and was not told of the neurological side effects. I honestly think she had a reaction to the medication. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fidos digestive tract, rather than his nervous system. Next she developed severe tremors. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. I removed it immediately She just tested positive for Lyme's. HELP!! Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). It kills heartworm larvae by causing paralysis that leads to the death of the parasite. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. My dog is having seizures. I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. On the first day he woke up and peed in my bedroom floor. I am also very worried about him. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. She's been given this dosage for over a year. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. You ask why they are giving this poison to our furbabies, it's easy. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. In total we spend around $780 trying to control/stop the tremors & seizures. He has never done this, and when I heard it and woke up he couldn't stop. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. He just isnt himself. She has what is called knuckling. I hope we get to the bottom of it as this is not fun. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Now tremors started. My 5 year old Fox Hound isnow drinking lots of water and urinating in the house! My dog is currently in an emergency hospital in Chicago with my daughter. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. Seizures continue and its Monday. Called his vet and they gave no information. It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. He first started with seizures and losing weight in June after giving him Simparica. It sounds as if she's been pinched while sleeping although nothing visible happened. Good appetite and no digestive issues (never had that symptom). This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Once again peed in my office on Saturday. A week after I lost her I got COVID and was in the hospital for 20 days. Certain age, breed predispositions. Not even going to risk it . he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. I returned that medicine back to the vet and bought Revolution! The vet does not feel it is due to Simparica but i think it could be. 300+ Cute Cat Names for Every Kind of Kitty. The FDA considers this level to be "very rare". 10 days after taking Simparica, she started having muscle tremors. I don't know if the lump came from it or something else. It has been five days and the diarrhea started on day 2. She text me asking if she ever had seizures before. I pray for my baby to be ok and all of you who are in this battle. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. This was January 15 of 2020. I disagree. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. My vet is aware of this and prescribed simparica. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. I will never give my dog this medication again. Very dissapointed with my vet for not informing me of the risk this has on my dog. I just gave Bentlee my Akita Simparica Trio on the 9th. He has no appetite and very little drinking either so hes not using the bathroom much. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. Thankfully there have been no other side effects. My dog is having the same issues. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. org to have this poison recalled. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! He is eating fine with no diarrhea or vomiting. I called my Vet and waited all day for them to call back, useless. It seems to be clearing up with Rx eye drops. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. I just wish I could find a vet who honestly loves my animals as much as I do. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. after a few months of this i decided to go back to Sentinel and Bravecto. He is pissing a lot and often and drinking a lot of water. Seems like it was directly related to the medication. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. He scratched at them which made it worse. On Jan 4th for the first time. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. He woke up and seemed much brighter. He drank not crazy about dog food . He has no appetite, wont drink water and his mouth is so dry. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it.